The role of IL-4 gene polymorphism in HCV-related hepatocellular carcinoma in Egyptian patients

Abstract Background Interleukin-4 (IL-4), a pleiotropic anti-inflammatory cytokine, is produced mainly by activated T helper 2 (Th2). Hepatocellular carcinoma (HCC) typical inflammation-related cancer. Alterations influencing IL-4 expression may disturb immune response and be associated with HCC risk. We aimed to verify role of IL4 gene polymorphism ( IL-4-589C/T (rs2243250 )) in HCV-related hepatocellular Egyptian patients. ) was examined 50 patients on top HCV, 40 HCV-induced liver cirrhosis, 30 healthy controls using the polymerase chain reaction- restriction fragment length method. Results Overall showed significant difference between group versus cirrhosis control groups. TT homozygous genotype more prevalent (24%) (5%) (3.3%) control. had 10 times risk 6.33 cirrhotic p value = 0.018 0.016 respectively). Conclusion (rs2243250) polymorphism, genetic model, factor